Integrating brain function and structure in the study of the human attentional networks: a functionnectome study Martín Signes, Mar Paz-Alonso, Pedro M. Thiebaut de Schotten, Michel Chica Martínez, Ana Belén Attention Phasic alerting Spatial orienting Executive attention fMRI White matter Attention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has extensively characterized their functioning, the role of white matter in cognitive function has gained recent interest due to diffusion-weighted imaging advancements. However, most evidence relies on correlations between white matter properties and behavioral or cognitive measures. This study used a new method that combines the signal from distant voxels of fMRI images using the probability of structural connection given by high-resolution normative tractog- raphy. We analyzed three fMRI datasets with a visual perceptual task and three attentional manipulations: phasic alerting, spatial orienting, and executive attention. The phasic alerting network engaged temporal areas and their communication with frontal and parietal regions, with left hemisphere dominance. The orienting network involved bilateral fronto-parietal and midline regions communicating by association tracts and interhemispheric fibers. The executive attention network engaged a broad set of brain regions and white matter tracts connecting them, with a particular involvement of frontal areas and their connections with the rest of the brain. These results partially confirm and extend previous knowledge on the neural substrates of the attentional system, offering a more comprehensive understanding through the integration of structure and function. 2024-07-10T11:04:37Z 2024-07-10T11:04:37Z 2024-07-06 journal article Martín-Signes, M., Paz-Alonso, P. M., Thiebaut de Schotten, M., & Chica, A. B. (2024). Integrating brain function and structure in the study of the human attentional networks: a functionnectome study. Brain Structure and Function, 1-15. https://hdl.handle.net/10481/93059 https://doi.org/10.1007/s00429-024-02824-1 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Springer Nature