Nanomedicine in Pancreatic Cancer: A New Hope for Treatment Redruello Guerrero, Pablo Perazzoli, Gloria Cepero, Ana Quiñonero Muñoz, Francisco José Mesas Hernández, Cristina Doello, Kevin Láinez Ramos-Bossini, Antonio Jesús Rivera Izquierdo, Mario Melguizo Alonso, Consolación Prados Salazar, José Carlos Pancreatic ductal adenocarcinoma Chemotherapeutic drugs Nanoparticles Pancreatic ductal adenocarcinoma (PDA) has one of the worst prognosis and higher mortality among most cancers. The diagnosis of PDA is frequently delayed due to a lack of specific biomarkers, and the efficacy of current chemotherapeutic drugs is limited. Moreover, chemotherapy is generally applied in advanced stages, where metastatic spread has already occurred. Nanotechnologybased systems are allowing to advance in the diagnosis and treatment of PDA. New nanoformulations have shown to improve the activity of conventional chemotherapeutic agents, such as gemcitabine, and new antitumor drugs, protecting them from degradation, improving their selectivity, solubility and bioavailability, and reducing their side effects. Moreover, the design of nanocarriers represents a new way to overcome drug resistance, which requires a comprehensive understanding of the tumor microenvironment of PDA. This article reviews the current perspectives, based on nanomedicine, to address the limitations of pancreatic cancer treatment, and the futures lines of research to progress in the control of this disease 2024-06-13T07:35:49Z 2024-06-13T07:35:49Z 2024 journal article Published version: Redruello, P., Perazzoli, G., Cepero, A., Quinonero, F., Mesas, C., Doello, K., ... & Prados, J. (2020). Nanomedicine in pancreatic cancer: a new hope for treatment. Current Drug Targets, 21(15), 1580-1592. [https://doi.org/10.2174/1389450121666200703195229] https://hdl.handle.net/10481/92554 10.2174/1389450121666200703195229 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Bentham Science