Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue Jurado Fasoli, Lucas Sanchez‑Delgado, Guillermo Di, Xinyu Yang, Wei Kohler, Isabelle Villarroya, Francesc Aguilera García, Concepción María Hankemeier, Thomas Ruiz Ruiz, Jonatan Martínez Téllez, Borja Manuel Cold exposure activates brown adipose tissue (BAT) and potentially improves cardiometabolic health through the secretion of signaling lipids by BAT. Here, we show that 2 h of cold exposure in young adults increases the levels of omega-6 and omega-3 oxylipins, the endocannabinoids (eCBs) anandamide and docosahexaenoylethanolamine, and lysophospholipids containing polyunsaturated fatty acids. Contrarily, it decreases the levels of the eCBs 1-LG and 2-LG and 1-OG and 2-OG, lysophosphatidic acids, and lysophosphatidylethanolamines. Participants overweight or obese show smaller increases in omega-6 and omega-3 oxylipins levels compared to normal weight. We observe that only a small proportion (~4% on average) of the cold-induced changes in the plasma signaling lipids are slightly correlated with BAT volume. However, cold-induced changes in omega-6 and omega-3 oxylipins are negatively correlated with adiposity, glucose homeostasis, lipid profile, and liver parameters. Lastly, a 24-week exercise-based randomized controlled trial does not modify plasma signaling lipid response to cold exposure. 2024-05-28T07:56:23Z 2024-05-28T07:56:23Z 2024-01-22 journal article Jurado-Fasoli et al., 2024, Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue, Cell Reports Medicine 5, 101387 [10.1016/j.xcrm.2023.101387] https://hdl.handle.net/10481/92135 10.1016/j.xcrm.2023.101387 eng info:eu-repo/grantAgreement/EC/NextGenerationEU/RR_C_2021_04 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier