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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/92113">
      <dc:title>Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression</dc:title>
      <dc:creator>Vázquez de Ágredos Martín Gil, Ana</dc:creator>
      <dc:creator>Valero, Marta</dc:creator>
      <dc:creator>Aparicio-Mescua, Teresa</dc:creator>
      <dc:creator>García-Rodríguez, Raquel</dc:creator>
      <dc:creator>Gámiz Ruiz, Fernando</dc:creator>
      <dc:creator>Gallo Torre, Milagros</dc:creator>
      <dc:subject>Alcohol</dc:subject>
      <dc:subject>Anxiety-like behavior</dc:subject>
      <dc:subject>Basolateral amygdala</dc:subject>
      <dc:subject>C-Fos</dc:subject>
      <dc:subject>Epigenetic</dc:subject>
      <dc:subject>microARN</dc:subject>
      <dc:description>Adolescent binge alcohol drinking is a serious health concern contributing to adult alcohol abuse often associated with anxiety disorders. We have used adolescent intermittent ethanol (AIE) administration as a model of binge drinking in rats in order to explore its long-term effect on the basolateral amygdala (BLA) responsiveness to alcohol and anxiety-like behavior. AIE increased the number of BLA c-Fos positive cells in adult Wistar rats and anxiety-like behavior assessed by the open field test (OFT). Additionally, in adult female rats receiving AIE BLA over expression of miR-182 was found. Therefore, our results indicate that alcohol consumption during adolescence can lead to enduring changes in anxiety-like behavior and BLA susceptibility to alcohol that may be mediated by sex-dependent epigenetic changes. These results contribute to understanding the mechanisms involved in the development of alcohol use disorders (AUD) and anxiety-related disorders.</dc:description>
      <dc:date>2024-05-27T11:45:29Z</dc:date>
      <dc:date>2024-05-27T11:45:29Z</dc:date>
      <dc:date>2024</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>https://hdl.handle.net/10481/92113</dc:identifier>
      <dc:identifier>10.1016/j.pbb.2024.173741</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Elservier</dc:publisher>
   </ow:Publication>
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