Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross‑Sectional Study Cadenas Sánchez, Cristina Hidalgo Migueles, Jairo Torres López, Lucía Victoria Verdejo Román, Juan Jiménez Pavón, David Hillman, Charles H. Catena Martínez, Andrés Ortega Porcel, Francisco Bartolomé Brain shapes Grey matter Obesity Objectives To examine the relationship between sleep and subcortical brain structures using a shape analysis approach. Methods A total of 98 children with overweight/obesity (10.0 ± 1.1 y, 59 boys) were included in the cross-sectional analyses. Sleep behaviors (i.e., wake time, sleep onset time, total time in bed, total sleep time, sleep efficiency, and wakening after sleep onset) were estimated with wrist-worn accelerometers. The shape of the subcortical brain structures was acquired by magnetic resonance imaging. A partial correlation permutation approach was used to examine the relationship between sleep behaviors and brain shapes. Results Among all the sleep variables studied, only total time in bed was significantly related to pallidum and putamen structure, such that those children who spent more time in bed had greater expansions in the right and left pallidum (211–751 voxels, all p’s <0.04) and right putamen (1783 voxels, p = 0.03). Conclusions These findings suggest that more time in bed was related to expansions on two subcortical brain regions in children with overweight/obesity. 2024-05-24T07:06:06Z 2024-05-24T07:06:06Z 2024-03-04 journal article Cadenas-Sanchez, C., Migueles, J.H., Torres-Lopez, L.V. et al. Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional Study. Indian J Pediatr (2024). https://doi.org/10.1007/s12098-024-05094-1 https://hdl.handle.net/10481/92029 10.1007/s12098-024-05094-1 eng info:eu-repo/grantAgreement/EC/H2020/MSC 101028929 info:eu-repo/grantAgreement/EC/H2020/667302 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature