High-risk pregnancy and its relationship with the neurodevelopment and behavior of 2-year-old children Mariño Narváez, Carolina Puertas González, José Antonio Romero González, Borja Cruz Martínez, Milagros González Pérez, Raquel Juncosa-Castro, Yaima Peralta Ramírez, María Isabel Child development Cortisol High-risk pregnancy High-risk pregnancies elevate maternal stress, impacting offspring neurodevelopment and behavior. This study, involving 112 participants, aimed to compare perceived stress, neurodevelopment, and behavior in high-risk and low-risk pregnancies. Two groups, high-risk and lowrisk, were assessed during pregnancy for stress using hair cortisol and psychological analysis. At 24 months post-birth, their children’s neurodevelopment and behavior were evaluated. Results revealed higher perceived stress and pregnancy-related concerns in high-risk pregnancies, contrasting with low-risk pregnancies. Offspring from high-risk pregnancies displayed elevated internalizing behavior scores, while low-risk pregnancies showed higher externalizing behavior scores. Additionally, women in low-risk pregnancies exhibited increased cortisol concentrations 24 months post-delivery. These findings underscore the necessity for early stress detection and prevention programs during pregnancy, particularly in high-risk cases, to enhance maternal and infant health. 2024-05-15T09:45:27Z 2024-05-15T09:45:27Z 2024-04-17 journal article Mariño-Narvaez C, Puertas-Gonzalez JA, Romero-Gonzalez B, et al. High-risk pregnancy and its relationship with the neurodevelopment and behavior of 2-year-old children. Development and Psychopathology. Published online 2024:1-8. [doi:10.1017/S0954579424000786] https://hdl.handle.net/10481/91807 10.1017/S0954579424000786 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Cambridge University Press