Isolation and Antitumoral Effect of a New Siphonochilone Derivative from African Ginger Fuentes-Ríos, David Ortigosa Palomo, Alba Quiñonero Muñoz, Francisco José Melguizo Alonso, Consolación Ortiz Quesada, Raúl Prados Salazar, José Carlos Díaz, Amelia López Romero, Juan Manuel The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsomega.4c01914. A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan-5-yl acetate (1), has been isolated from the rhizomes of the South African variety of wild ginger (Siphonochilus aethiopicus (Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclear magnetic resonance spectroscopy (NMR) and mass-spectrometric (MS) analyses, including 1D-, 2D-NMR, and HR-LCMS. We also investigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous system cancer lines. The data are not encouraging since its antitumor effect is poor. Nonetheless, the discovery of new molecules may provide a source of new compounds with important biological effects applicable to the field of medicine. 2024-05-10T10:45:50Z 2024-05-10T10:45:50Z 2024-03-20 journal article ACS Omega 2024, 9, 13, 15718–15722 [https://doi.org/10.1021/acsomega.4c01914] https://hdl.handle.net/10481/91644 10.1021/acsomega.4c01914 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional American Chemical Society