Three-year study of antibody to Borrelia burgdorferi in southern Spain Gutiérrez Fernández, José Maroto Vela, María del Carmen De La Higuera, A. Guerrero, M. Padilla, E. Piédrola Angulo, Gonzalo The prevalence of anti-Borrelia burgdorferi antibodies was studied in Granada, Spain, between January 1991 and November 1993 in 354 patients with suspected Lyme disease (group 1); in 50 patients either with syphilis (n = 32) or without syphilis but with a positive Rapid Plasma Reagin test (n = 18) (group 2); and in 150 healthy subjects (group 3). In addition, intrathecal antibody production was evaluated by EIA in CSF samples obtained from 117 patients in group 1. Anti-Borrelia burgdorferi antibodies were detected by EIA in 58 patients (16.4%) in group 1, 29 (8.2%) of whom were positive by Western blot. Intrathecal antibody production was detected in one patient. In group 2, 8 (16%) patients had a positive EIA result, but none of these was confirmed by Western blot. western blot was negative for all subjects in group 3. The results of this study indicate that anti-Borrelia burgdorferi antibodies are not uncommon in our area, although Lyme disease is rare. 2024-05-07T07:54:59Z 2024-05-07T07:54:59Z 1995-06 journal article Gutierrez, J., Maroto, M.C., De la Higuera, A. et al. Three-year study of antibody toBorrelia burgdorferi in Southern Spain. Eur. J. Clin. Microbiol. Infect. Dis. 14, 542–546 (1995). https://doi.org/10.1007/BF02113437 https://hdl.handle.net/10481/91464 10.1007/BF02113437 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Springer Nature