Light-to-Heat Conversion of Optically Trapped Hot Brownian Particles Ortiz Rivero, Elisa Orozco Barrera, Sergio Chatterjee, Hirak González Gómez, Carlos D. Caro, Carlos García Martín, María Luisa Haro González, Patricia Rica Alarcón, Raúl Alberto Gámez Márquez, Francisco Optical tweezers Hybrid nanostructures Heat generation Anisotropic hybrid nanostructures stand out as promising therapeutic agents in photothermal conversion-based treatments. Accordingly, understanding local heat generation mediated by light-to-heat conversion of absorbing multicomponent nanoparticles at the single-particle level has forthwith become a subject of broad and current interest. Nonetheless, evaluating reliable temperature profiles around a single trapped nanoparticle is challenging from all of the experimental, computational, and fundamental viewpoints. Committed to filling this gap, the heat generation of an anisotropic hybrid nanostructure is explored by means of two different experimental approaches from which the local temperature is measured in a direct or indirect way, all in the context of hot Brownian motion theory. The results were compared with analytical results supported by the numerical computation of the wavelength-dependent absorption efficiencies in the discrete dipole approximation for scattering calculations, which has been extended to inhomogeneous nanostructures. Overall, we provide a consistent and comprehensive view of the heat generation in optical traps of highly absorbing particles from the viewpoint of the hot Brownian motion theory. 2024-04-29T08:17:21Z 2024-04-29T08:17:21Z 2023-12-04 journal article Elisa Ortiz-Rivero, Sergio Orozco-Barrera, Hirak Chatterjee, Carlos D. González-Gómez, Carlos Caro, María-Luisa García-Martín, Patricia Haro González, Raúl A. Rica, and Francisco Gámez. ACS Nano. 2023 17 (24), 24961-24971. DOI: 10.1021/acsnano.3c07086 https://hdl.handle.net/10481/91239 10.1021/acsnano.3c07086 eng info:eu-repo/grantAgreement/EC/NextGenerationEU/CTQ2017-86655-R info:eu-repo/grantAgreement/EC/H2020/MSC 101065163 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional American Chemical Society