Interplay of Postprandial Triglyceride-Rich Lipoprotein Composition and Adipokines in Obese Adolescents García Rodríguez, Silvia Espinosa Cabello, Juan M. García González, Aída González Jiménez, Emilio Aguilar Cordero, Josefa Castellano, Jose M. Perona, Javier S. Obesity Adolescence Postprandial In the context of the alarming rise of infant obesity and its health implications, the present research aims to uncover disruptions in postprandial lipid metabolism and the composition of triglyceride-rich lipoproteins in obese adolescents. A double-blind, controlled clinical trial in the postprandial phase on 23 adolescents aged 12 to 16 years was carried out. Twelve participants were categorized as obese (BMI > 30 kg/m2 and percentile > 95) and 11 as normal-weight (BMI = 20–25 kg/m2, percentile 5–85). Blood samples were collected after a 12-h overnight fast and postprandially after consumption of a standardized breakfast containing olive oil, tomato, bread, orange juice, and skimmed milk. Obese adolescents exhibited elevated triglyceride concentrations in both fasting and postprandial states and higher TG/apo-B48 ratios, indicating larger postprandial triglyceride-rich lipoprotein (TRL) particle size, which suggests impaired clearance. Obese subjects also exhibited higher n-6 PUFA concentrations, potentially linked to increased TRL hydrolysis and the release of pro-inflammatory adipokines. In contrast, TRL from normal-weight individuals showed higher concentrations of oleic acid and DHA (n-3 PUFA), with possible anti-inflammatory effects. The results indicate an interplay involving postprandial TRL metabolism and adipokines within the context of adolescent obesity, pointing to potential cardiovascular implications in the future. 2024-04-24T10:14:58Z 2024-04-24T10:14:58Z 2024-01-16 journal article García-Rodríguez, S.; Espinosa-Cabello, J.M.; García-González, A.; González-Jiménez, E.; Aguilar-Cordero, M.J.; Castellano, J.M.; Perona, J.S. Interplay of Postprandial Triglyceride-Rich Lipoprotein Composition and Adipokines in Obese Adolescents. Int. J. Mol. Sci. 2024, 25, 1112. https://doi.org/10.3390/ijms25021112 https://hdl.handle.net/10481/91119 10.3390/ijms25021112 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI