<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/91044">
      <dc:title>Exploring the Impact of Nanoparticle Stealth Coatings in Cancer Models: From PEGylation to Cell Membrane-Coating Nanotechnology</dc:title>
      <dc:creator>Graván, Pablo</dc:creator>
      <dc:creator>Peña Martín, Jesús</dc:creator>
      <dc:creator>López de Andrés, Julia</dc:creator>
      <dc:creator>Pedrosa Bustos, María</dc:creator>
      <dc:creator>Villegas Montoya, Martín</dc:creator>
      <dc:creator>Galisteo González, Francisco</dc:creator>
      <dc:creator>Marchal Corrales, Juan Antonio</dc:creator>
      <dc:creator>Sánchez Moreno, Paola</dc:creator>
      <dc:subject>Nanoparticles</dc:subject>
      <dc:subject>Coatings</dc:subject>
      <dc:subject>Cell membranes</dc:subject>
      <dc:description>Nanotechnological platforms offer advantages over conventional&#xd;
therapeutic and diagnostic modalities. However, the efficient biointerfacing of&#xd;
nanomaterials for biomedical applications remains challenging. In recent years,&#xd;
nanoparticles (NPs) with different coatings have been developed to reduce&#xd;
nonspecific interactions, prolong circulation time, and improve therapeutic&#xd;
outcomes. This study aims to compare various NP coatings to enhance surface&#xd;
engineering for more effective nanomedicines. We prepared and characterized&#xd;
polystyrene NPs with different coatings of poly(ethylene glycol), bovine serum&#xd;
albumin, chitosan, and cell membranes from a human breast cancer cell line. The&#xd;
coating was found to affect the colloidal stability, adhesion, and elastic modulus of&#xd;
NPs. Protein corona formation and cellular uptake of NPs were also investigated,&#xd;
and a 3D tumor model was employed to provide a more realistic representation&#xd;
of the tumor microenvironment. The prepared NPs were found to reduce protein&#xd;
adsorption, and cell-membrane-coated NPs showed significantly higher cellular uptake. The secretion of proinflammatory cytokines&#xd;
in human monocytes after incubation with the prepared NPs was evaluated. Overall, the study demonstrates the importance of&#xd;
coatings in affecting the behavior and interaction of nanosystems with biological entities. The findings provide insight into bionano&#xd;
interactions and are important for the effective implementation of stealth surface engineering designs.</dc:description>
      <dc:date>2024-04-23T07:35:04Z</dc:date>
      <dc:date>2024-04-23T07:35:04Z</dc:date>
      <dc:date>2023-12-30</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Graván, Pablo, et al. "Exploring the Impact of Nanoparticle Stealth Coatings in Cancer Models: From PEGylation to Cell Membrane-Coating Nanotechnology." ACS Applied Materials &amp; Interfaces 16.2 (2023): 2058-2074 [10.1021/acsami.3c13948]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/91044</dc:identifier>
      <dc:identifier>10.1021/acsami.3c13948</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>American Chemical Society</dc:publisher>
   </ow:Publication>
</rdf:RDF>