<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/91036">
      <dc:title>Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs</dc:title>
      <dc:creator>Rodríguez Carrillo, Andrea</dc:creator>
      <dc:creator>Verheyen, Veerle J.</dc:creator>
      <dc:creator>Van Nuijs, Alexander L. N.</dc:creator>
      <dc:creator>Fernández Cabrera, Mariana Fátima</dc:creator>
      <dc:creator>Remy, Sylvie</dc:creator>
      <dc:subject>Brain-derived neurotrophic factor</dc:subject>
      <dc:subject>Neurodevelopment</dc:subject>
      <dc:subject>Human biomonitoring</dc:subject>
      <dc:description>The present narrative review summarizes recent findings focusing on the role of&#xd;
brain-derived neurotrophic factor (BDNF) as a biomarker of effect for&#xd;
neurodevelopmental alterations during adolescence, based on health effects of&#xd;
exposure to environmental chemical pollutants. To this end, information was&#xd;
gathered from the PubMed database and the results obtained in the European&#xd;
project Human Biomonitoring for Europe (HBM4EU), in which BDNF was&#xd;
measured at two levels of biological organization: total BDNF protein (serum) and&#xd;
BDNF gene DNA methylation (whole blood) levels. The obtained information is&#xd;
organized as follows. First, human biomonitoring, biomarkers of effect and the&#xd;
current state of the art on neurodevelopmental alterations in the population are&#xd;
presented. Second, BDNF secretion and mechanisms of action are briefly explained.&#xd;
Third, previous studies using BDNF as an effect biomarker were consulted in PubMed&#xd;
database and summarized. Finally, the impact of bisphenol A (BPA), metals, and nonpersistent&#xd;
pesticide metabolites on BDNF secretion patterns and its mediation role&#xd;
with behavioral outcomes are addressed and discussed. These findingswere obtained&#xd;
from three pilot studies conducted in HBM4EU project. Published findings suggested&#xd;
that exposure to some chemical pollutants such as fine particle matter (PM), PFAS,&#xd;
heavy metals, bisphenols, and non-persistent pesticides may alter circulating BDNF&#xd;
levels in healthy population. Therefore, BDNF could be used as a valuable effect&#xd;
biomarker to investigate developmental neurotoxicity of some chemical pollutants.</dc:description>
      <dc:date>2024-04-23T06:56:44Z</dc:date>
      <dc:date>2024-04-23T06:56:44Z</dc:date>
      <dc:date>2024-01-10</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Rodríguez-Carrillo A, Verheyen VJ, Van Nuijs ALN, Fernández MF and Remy S (2024), Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs. Front. Toxicol. 5:1319788. doi: 10.3389/ftox.2023.1319788</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/91036</dc:identifier>
      <dc:identifier>10.3389/ftox.2023.1319788</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:relation>info:eu-repo/grantAgreement/EC/H2020/733032</dc:relation>
      <dc:relation>info:eu-repo/grantAgreement/EC/H2020/101057014</dc:relation>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>Frontiers Media</dc:publisher>
   </ow:Publication>
</rdf:RDF>