Impact of Work–Life Balance on the Quality of Life of Spanish Nurses during the Sixth Wave of the COVID-19 Pandemic: A Cross-Sectional Study Antolí Jover, Ana María Alvarez Serrano, Maria Adelaida Gázquez López, María Martín Salvador, Adelina Pérez Morente, María Ángeles Martínez García, Encarnación García García, Inmaculada Health-related quality of life EQ-5D Work–life balance Nurse COVID-19 This study addresses the health-related quality of life (HRQoL) of Spanish nurses during the sixth wave of the COVID-19 pandemic, assessed through the EQ-5D and EQ-VAS indices. Methods: This cross-sectional 334 study used online surveys, recruiting 305 Spanish nurses. Results: Nurses generally perceived a good HRQoL. “Negative work–family interaction” is adversely associated with the EQ-VAS (β = −0.337, 95% CI [−1.733, −0.723]) and EQ-5D (β = −0.399, 95% CI [−0.021, −0.01]) indices, while “positive work–family interaction” shows a positive relationship with the EQ-VAS (β = 0.218, 95% CI [0.381, 1.759]). The presence of a “paid supportive caregiver” is positively associated with the EQ-VAS (β = 0.18, 95% CI [1.47, 12.3]) and EQ-5D (β = 0.149, 95% CI [0.004, 0.117]) indices, but a higher “number of children” is negatively linked with the EQ-5D index (β = −0.146, 95% CI [−0.061, −0.002]). In addition, living with a partner (EQ-VAS β = 0.16, 95% CI [1.094, 14.67] and EQ-5D index β = 0.174, 95% CI [0.018, 0.163]) and working a “rotating shift” (EQ-5D index β = 0.158, 95% CI [0.005, 0.098]) are positively associated. Conclusions: These findings highlight the need to comprehensively address nurses’ well-being, considering both their working conditions and their home environment, especially in crisis contexts such as the current pandemic. 2024-04-23T06:51:08Z 2024-04-23T06:51:08Z 2024-03-06 info:eu-repo/semantics/article Antolí-Jover, A.M.; Álvarez-Serrano, M.A.; Gázquez-López, M.; Martín-Salvador, A.; Pérez-Morente, M.Á.; Martínez-García, E.; García-García, I. Impact of Work–Life Balance on the Quality of Life of Spanish Nurses during the Sixth Wave of the COVID-19 Pandemic: A Cross-Sectional Study. Healthcare 2024, 12, 598. https://doi.org/10.3390/healthcare12050598 https://hdl.handle.net/10481/91034 https://doi.org/10.3390/healthcare12050598 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional MDPI