From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin Fernández Martínez, José Ramírez Casas, Yolanda Yang, Yang Aranda Martínez, Paula Martínez Ruiz, Laura Escames Rosa, Germaine Acuña Castroviejo, Darío Aging Chronodisruption Clock genes Sarcopenia is an age-related condition that involves a progressive decline inmusclemass and function, leading to increased risk of falls, frailty, andmortality. Although the exactmechanisms are not fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on mitochondria and organelle, where it is synthesized and crucial in aging skeletal muscle, further highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with melatonin, which is proposed as a potential therapy against sarcopenia. 2024-04-17T10:58:56Z 2024-04-17T10:58:56Z 2023-12-12 journal article Fernández-Martínez, J.; Ramírez-Casas, Y.; Yang, Y.; Aranda-Martínez, P.;Martínez-Ruiz, L.; Escames, G.; Acuña-Castroviejo, D. From Chronodisruption to Sarcopenia: The Therapeutic Potential ofMelatonin. Biomolecules 2023, 13, 1779. https://doi.org/10.3390/biom13121779 https://hdl.handle.net/10481/90834 10.3390/biom13121779 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI