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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/90550">
      <dc:title>Clinical Reliability of IgG, IgA, and IgM Antibodies in Detecting Epstein-Barr Virus at Different Stages of Infection With a Commercial Nonrecombinant Polyantigenic ELISA</dc:title>
      <dc:creator>Gutiérrez Fernández, José</dc:creator>
      <dc:creator>Vergara, M.J.</dc:creator>
      <dc:creator>Piédrola Angulo, Gonzalo</dc:creator>
      <dc:creator>Maroto Vela, María del Carmen</dc:creator>
      <dc:subject>Epstein-Barr virus</dc:subject>
      <dc:subject>ELISA</dc:subject>
      <dc:subject>Antibodies</dc:subject>
      <dc:description>We studied the diagnostic reliability of a modification of the Enzygnost EBV test (Behringwerke, Germany) for the detection of IgG, IgA, and IgM antibodies (Abs) in the diagnosis of Epstein-Barr virus (EBV) disease. One hundred and twenty-three serum samples were studied: 14 asymptomatic subjects without EBV infection, 48 patients with primary infection, 46 subjects with past EBV infection (11 patients with other acute infections), 8 patients without EBV infection but with other viral infection, and 7 patients with probable acute clonal stimulation of B lymphocytes caused by different microorganisms. Enzygnost EBV is based on an ELISA test with a pool of viral antigens. In our series the reliability of IgM for the diagnosis of recent primary EBV infection was: sensitivity 100%, specificity 95%, positive predictive value 90.5%, and negative predictive value 100%. The IgG detection with Enzygnost was: sensitivity 98%, specificity 100%, positive predictive value 100%, and negative predictive value 91.7%. Only two subjects had positive IgA. The Enzygnost test is an efficient method for the diagnosis of EBV infection although a few IgM false positives can occur.</dc:description>
      <dc:date>2024-04-09T11:10:09Z</dc:date>
      <dc:date>2024-04-09T11:10:09Z</dc:date>
      <dc:date>1999-02-11</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Gutiérrez et al. Clinical reliability of IgG, IgA, and IgM antibodies in detecting Epstein-Barr virus at different stages of infection with a commercial nonrecombinant polyantigenic ELISA. J Clin Lab Anal. 1999;13(2):65-8. https://doi.org/10.1002/(SICI)1098-2825(1999)13:2&lt;65::AID-JCLA4>3.0.CO;2-O</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/90550</dc:identifier>
      <dc:identifier>10.1002/(SICI)1098-2825(1999)13:2&lt;65::AID-JCLA4>3.0.CO;2-O</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Wiley</dc:publisher>
   </ow:Publication>
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