Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults Di, Xinyu Martínez Téllez, Borja Manuel Krekels, Elke H.J. Jurado Fasoli, Lucas Osuna Prieto, Francisco Javier Ortiz Álvarez, Lourdes Hankemeier, Thomas Rensen, Patrick C. N. Ruiz Ruiz, Jonatan Kohler, Isabelle Body composition Cardiometabolic risk factors Anandamide Context: The endocannabinoid system (ECS) is a signaling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases. Objective: Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors. Methods: The study included 133 young adults (age 22.1 ± 2.2 years, 67% women). Fasting plasma levels of eCBs and their analogues were measured using liquid chromatography-tandem mass spectrometry. Body composition, brown adipose tissue (BAT) volume, glucose uptake, and traditional cardiometabolic risk factors were measured. Results: Plasma levels of eCBs and several eCB analogues were positively correlated with adiposity and traditional cardiometabolic risk factors (eg, serum insulin and triacylglyceride levels, all r ≥ 0.17 and P ≤ .045). Plasma levels of 2-arachidonoyl glycerol and N-pentadecenoylethanolamine were negatively correlated with BAT volume and glucose uptake (all r ≤ −0.17 and P ≤ .047). We observed that the plasma levels of eCBs and their analogues were higher in metabolically unhealthy overweight–obese participants than in metabolically healthy overweight–obese participants. Conclusion: Our findings show that the plasma levels of eCBs and their analogues are related to higher levels of adiposity and worse cardiometabolic profile. 2024-04-04T06:55:00Z 2024-04-04T06:55:00Z 2023-11-15 journal article The Journal of Clinical Endocrinology & Metabolism, 2023, 00, 1–10 [10.1210/clinem/dgad668] https://hdl.handle.net/10481/90377 10.1210/clinem/dgad668 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Oxford University Press