Expression of the p53 protein in oral squamous cell carcinomas associated with Epstein-Barr virus González Moles, Miguel Ángel Galindo Moreno, Pablo Antonio Gutiérrez Fernández, José Rodríguez Archilla, Alberto Ruiz Ávila, María Isabel Sánchez Fernández, Elena The behaviour of the p53 protein has been investigated in some human carcinomas associated with Epstein-Barr virus (EBV) but not in EBV-positive oral squamous cell carcinomas (OSCC). The present study aimed to compare the p53 protein expression in EBV-positive OSCC with that in EBV-negative OSCC. The cases had been gathered in a study previously published. An immunohistochemical technique with BP53-12 monoclonal antibody was applied on 74 of the 107 OSCC from the earlier work. The nuclear or cytoplasmic expression of the p53 protein was classified as, absent (0% of neoplastic cells positive), mild (<25% positive), moderate (25-30% positive), or extensive (>50% positive). The p53 protein was expressed by 60.8% of the OSCC. Out of the fourteen EBV-positive OSCC, 57.1% (8 cases) expressed p53, always in the nucleus and never in the cytoplasm. Of the 60 EBV-negative OSCC, 61.6% (37 cases) expressed the p53 protein. Of 37 cases 33 (89.1%) showed nuclear expression of p53 and nineteen cases (51.3%) revealed cytoplasmic expression. There was a statistically significant inverse correlation between cytoplasmic expression of the p53 protein and the presence of EBV DNA (p <0.01). Thus, the EBV-positive tumours less frequently expressed p53 in the cytoplasm. No evidence of an accumulation of the p53 protein in OSCC associated with EBV was recorded. 2024-04-03T09:34:31Z 2024-04-03T09:34:31Z 2000-01 info:eu-repo/semantics/article González-Moles MA, Galindo P, Gutierrez J, Rodriguez-Archilla A, Ruiz-Avilla I, Sanchez-Fernandez E. Expression of the p53 protein in oral squamous cell carcinomas associated with Epstein-Barr virus. Microbios. 2000;102(403):147-54. PMID: 10955828. https://hdl.handle.net/10481/90356 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional The Faculty Press