Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part II: A systematic review in animals Rayo Morales, Raquel Segura Carretero, Antonio Borras Linares, María Isabel García Burgos, David Anti-sweet Diet-induced obesity Gymnema sylvestre This article, the second in a two-part series, continues the discussion on the nature of the relationship between the level of sweet taste suppression and eating behaviour, but in animal rather human subjects. In particular, the aim was to review the scientific literature on the impact that bioactive compounds that decrease oral sweet sensations have on intake, preference and physiological status in preclinical studies. This review was registered in the International Prospective Register of Systematic Reviews and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Scottish Intercollegiate Guidelines Network and covered original papers included in Web of Science, PubMed, Scopus, Food Science Source and Food Science and technology abstracts. We identified 28 peer-reviewed English-language studies that fit the topic and met the inclusion criteria. We identified three plant species, Gymnema sylvestre, Hovenia dulcis, and Ziziphus jujuba, that possess acute sweetness-inhibitory properties. When administered orally, these plants reduced neural responses to sweet stimuli and decreased consumption. However, studies on the longer-term effects of antisweet activity remain to be conducted. Translating the valuable insights into the mechanisms underlying the relationship between sweet taste impairment and eating behaviour into practical clinical applications are discussed. 2024-04-03T07:26:34Z 2024-04-03T07:26:34Z 2023 journal article Heliyon 9 (2023) e20511 [10.1016/j.heliyon.2023.e20511] https://hdl.handle.net/10481/90335 10.1016/j.heliyon.2023.e20511 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier