<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/89956">
      <dc:title>Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma</dc:title>
      <dc:creator>González Moles, Miguel Ángel</dc:creator>
      <dc:creator>Gutiérrez Fernández, José</dc:creator>
      <dc:creator>Rodríguez, M. J.</dc:creator>
      <dc:creator>Ruiz-Avila, I.</dc:creator>
      <dc:creator>Rodríguez-Archilla, Alberto</dc:creator>
      <dc:subject>Epstein-Barr virus</dc:subject>
      <dc:subject>Latent membrane protein-1</dc:subject>
      <dc:subject>Oral squa-mous cell carcinoma</dc:subject>
      <dc:description>Objectives: Epstein-Barr virus (EBV) is frequently associated with malignant cell transformation through the action of the oncoprotein latent membrane protein-1 (LMP-1). The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs.&#xd;
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Study design/methods: In a retrospective study of 78 OSCCs, we investigated the presence of the DNA of EBV by polymerase chain reaction, the expression of the oncoprotein LMP-1 by immunohistochemistry, and the presence of EBV-encoded RNA (EBER) by in situ hybridization.&#xd;
&#xd;
Results: EBV DNA was detected in 19.2% of the cases. Expression of LMP-1 in neoplastic cells was found in 85.7% of the EBV-positive OSCCs. EBV presence was significantly more frequent (P &lt;.05) in OSCCs localized on the lateral tongue. EBV-positive OSCCs more frequently presented (P &lt;.05) greater nuclear atypia.&#xd;
&#xd;
Conclusion: EBV can appear in latent form in OSCC and express its main oncoprotein, LMP-1.</dc:description>
      <dc:date>2024-03-13T09:07:17Z</dc:date>
      <dc:date>2024-03-13T09:07:17Z</dc:date>
      <dc:date>2002-03</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Gonzalez-Moles MA, Gutierrez J, Rodriguez MJ, Ruiz-Avila I, Rodriguez-Archilla A. Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma. Laryngoscope. 2002 Mar;112(3):482-7.  https://doi.org/10.1097/00005537-200203000-00014</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/89956</dc:identifier>
      <dc:identifier>10.1097/00005537-200203000-00014</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Wiley</dc:publisher>
   </ow:Publication>
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