<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/89927">
      <dc:title>P53 protein expression in oral squamous cell carcinoma. Survival analysis</dc:title>
      <dc:creator>González Moles, Miguel Ángel</dc:creator>
      <dc:creator>Galindo Moreno, Pablo Antonio</dc:creator>
      <dc:creator>Gutiérrez Fernández, José</dc:creator>
      <dc:creator>Sánchez Fernández, Elena</dc:creator>
      <dc:creator>Rodríguez Archilla, Alberto</dc:creator>
      <dc:creator>Ruiz Ávila, María Isabel</dc:creator>
      <dc:creator>Bravo Pérez, Manuel</dc:creator>
      <dc:subject>Oral squamous cell carcinoma</dc:subject>
      <dc:subject>P53</dc:subject>
      <dc:subject>Survival</dc:subject>
      <dc:subject>Tumor-free margins</dc:subject>
      <dc:description>Background: The present study aimed to analyze the pattern of p53 expression and its influence on survival in patients with oral squamous cell carcinoma (OSCC).&#xd;
&#xd;
Materials and methods: An immunohistochemical technique with BP53-12 antibody was performed on stored tissue from 78 patients with OSCC (intraoral cancer n=40; lip cancer n=38). The nuclear and cytoplasmic extension of p53 staining was assessed. Clinical and histopathological data were gathered and the patient survival was analyzed.&#xd;
&#xd;
Results: 57.7% (n=45) of the OSCCs expressed p53, with nuclear expression in 52.6% (n=41) of cases and cytoplasmic expression in 24.4% (n=19). The OSCCs with extensive nuclear expression of p53 showed dissociated patterns of invasion of adjacent tissues (p&lt;0.05). A greater extension of cytoplasmic expression of p53 most commonly appeared in tumors that were better-differentiated (p&lt;0.005), more keratinized (p&lt;0.01) and with less nuclear atypia (p&lt;0.05). The parameters that significantly influenced survival of patients were tumor localization (p&lt;0.01), size (p&lt;0.0001), lymph node invasion (p&lt;0.0001), clinical stage (p&lt;0.0001), differentiation degree (p&lt;0.01) and nucleargrade (p&lt;0.01).&#xd;
&#xd;
Conclusion: The expression of p53 protein did not behave as a marker of prognostic value in patients with OSCC.</dc:description>
      <dc:date>2024-03-12T08:47:55Z</dc:date>
      <dc:date>2024-03-12T08:47:55Z</dc:date>
      <dc:date>2001-07</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Gonzalez-Moles MA, Galindo P, Gutierrez-Fernandez J, Sanchez-Fernandez E, Rodriguez-Archilla A, Ruiz-Avila I, Bravo M. P53 protein expression in oral squamous cell carcinoma. survival analysis. Anticancer Res. 2001 Jul-Aug;21 (4B): 2889-94. DOI: 10.4103/jomfp.JOMFP_106_20</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/89927</dc:identifier>
      <dc:identifier>10.4103/jomfp.JOMFP_106_20</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>National Library of Medicine</dc:publisher>
   </ow:Publication>
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