Numerical modelling of magnetic nanoparticle behavior in an alternating magnetic field based on multiphysics coupling Ashofteh, Alireza Marqués, Rafael Callejas Zafra, Antonio Manuel Muñoz Beltrán, Rafael Melchor Rodríguez, Juan Manuel Magnetic Nanoparticle Hyperthermia Alternating magnetic field Drug delivery Multiphysics This research was funded by the Ministry of Science and Innovation, Spain grant numbers PID2019-106947RA-C22 and (FEDER) EQC2018-004508-P. In magnetic nanoparticle hyperthermia, the magnetic nanoparticles (MNPs) start oscillations when they are exposed to an alternating magnetic field, which may generate ultrasound waves. These resulting oscillations of nanoparticles can lead to the movement of drug carrier liposomes. In this study, a multiphysics coupling model of magnetic nanoparticle behavior in an alternating magnetic field was developed, implementing solid mechanics compliance parameters and piezomagnetic coupling matrices. A detailed sensitivity study was conducted to examine the effects of size and elastic modulus of MNPs, distribution and distance between two MNPs, elasticity and viscosity of the glycerol medium and mesh element sizes on the output displacement signals of MNPs. The results indicated that magnetic nanoparticles undergo some displacements when they are exposed to an alternating magnetic field. These oscillations may generate ultrasound waves, though the amount of displacement for each nanoparticle is negligibly small. It is expected that aggregated nanoparticles result in much higher oscillations. 2024-02-12T07:48:15Z 2024-02-12T07:48:15Z 2022-11-21 info:eu-repo/semantics/article A. Ashofteh, R. Marqués, A. Callejas, R. Muñoz & J. Melchor (2022) Numerical modelling of magnetic nanoparticle behavior in an alternating magnetic field based on multiphysics coupling, Mechanics of Advanced Materials and Structures, DOI: 10.1080/15376494.2022.2136805 1537-6532 https://hdl.handle.net/10481/88964 10.1080/15376494.2022.2136805 eng info:eu-repo/semantics/openAccess Taylor & Francis