Fibromyalgia: Gender differences and sleep-disordered breathing Prados García, Germán Miró Morales, María Elena Martínez Narváez-Cabeza de Vaca, María del Pilar Sánchez Gómez, Ana Isabel López, Salvador Sáez, Germán Gender differences Polysomnography Fibromyalgia Sleep-disordered breathing Objective. The prevalence of fibromyalgia (FM) is much lower in men than in women. Therefore, current knowledge about this chronic pain syndrome emerged mainly from research on women. The aim of the present study was to compare clinical symptoms and sleep parameters between women and men FM patients. Methods. Forty FM patients (18 men and 22 women) aged 48.00±8.45 years were evaluated with questionnaires on pain, sleep, fatigue, depression, anxiety and functional impact, and polysomnography (PSG). Results. 61% of men FM patients had an apnea-hypopnea index (AHI) greater than 15, compared to 31.8% of women, and desaturation index (DI) above five was twice more prevalent in men than in women. In addition, men patients had lower sleep quality (16.05±2.92% vs. 13.08±3.88%; p= 0.01) and slow wave sleep (SWS) (stage 3 duration: 9.02±7.84% vs. 14.44±7.32%; p= 0.03) than women. No differences were found between the two groups in level of pain, emotional distress, or daily functioning. However, pain in men, fatigue in women, and functional impact in both sexes seemed to be related to worse sleep quality. Also in women, alterations in total sleep time (TST) and rapid eye movement (REM) sleep features appeared to be related to emotional status. Conclusions. Alterations in sleep respiratory patterns were more highly prevalent in men than in women FM patients. More so in men FM patients, the alterations in sleep patterns, non-refreshing sleep, and other FM-related symptoms observed in this population might be part of a primary sleep-disordered breathing. 2024-02-12T07:46:45Z 2024-02-12T07:46:45Z 2013 journal article Prados, G., Miró, E., Martínez, M. P., Sánchez, A. I., López, S., & Sáez, G. (2013). Fibromyalgia: gender differences and sleep-disordered breathing. Clinical and experimental rheumatology, 31(6 Suppl 79), S102–S110. 1593098X https://hdl.handle.net/10481/88962 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Clinical and Experimental Rheumatology