Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: A therapeutic approach to overweight adolescents Guerendiain, Marcela Montes, Rosa López-Belmonte, Gema Martín-Matillas, Miguel Castellote, Ana Martín-Bautista, Elena Martí, Amelia Martínez, Alfredo Moreno, Luis Garagorri, Jesús Mª Wärnberg, Julia Caballero, Javier Marcos, Ascensión López-Sabater, M Carmen Campoy Folgoso, Cristina Adiposity cardiometabolic profile obese adolescents plasma fatty acids weight loss “This is an original manuscript published by Churchill Livingstone in Clinical Nutrition on February 2018, available at: doi: 10.1016/j.clnu.2016.11.006.” Background & aims: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the role of plasma FA levels as modulators of body fat and cardiometabolic risk markers, in overweight adolescents. Methods: A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase). Results: While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0. Conclusions: Modifications in plasma FA composition could help modulate adiposity and the cardiometabolic profile in anti-obesity programs aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss. 2024-02-09T09:39:46Z 2024-02-09T09:39:46Z 2018-02 journal article Guerendiain M, Montes R, López-Belmonte G, Martín-Matillas M, Castellote AI, Martín-Bautista E, Martí A, Martínez JA, Moreno L, Garagorri JM, Wärnberg J, Caballero J, Marcos A, López-Sabater MC, Campoy C; EVASYON Study Group. Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: A therapeutic approach to overweight adolescents. Clin Nutr. 2018 Feb;37(1):149-156. doi: 10.1016/j.clnu.2016.11.006. https://hdl.handle.net/10481/88820 doi: 10.1016/j.clnu.2016.11.006. spa http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Churchill Livingstone in Clinical Nutrition