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      <dc:title>Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges</dc:title>
      <dc:creator>López-Longarela, B</dc:creator>
      <dc:creator>Morrison, EE</dc:creator>
      <dc:creator>Tranter, JD</dc:creator>
      <dc:creator>Chahman-Vos, L</dc:creator>
      <dc:creator>Léonard, JF</dc:creator>
      <dc:creator>Gautier, JC</dc:creator>
      <dc:creator>Laurent, S</dc:creator>
      <dc:creator>Lartigau, A</dc:creator>
      <dc:creator>Boitier, E</dc:creator>
      <dc:creator>Sautier, L</dc:creator>
      <dc:creator>Carmona-Saez, P</dc:creator>
      <dc:creator>Martorell-Marugan, J</dc:creator>
      <dc:creator>Mellanby, RJ</dc:creator>
      <dc:creator>Pernagallo, S</dc:creator>
      <dc:creator>Ilyine, H</dc:creator>
      <dc:creator>Rissin, DM</dc:creator>
      <dc:creator>Duffy, DC</dc:creator>
      <dc:creator>Dear, JW</dc:creator>
      <dc:creator>Diaz Mochon, Juan José</dc:creator>
      <dc:description>Circulating microRNAs serve as stable and cross-species biomarkers. MicroRNA-122 (miR-122) is a reliable hepatocyte-specific biomarker for drug-induced liver injury (DILI). We developed a dynamic chemical labeling (DCL) assay enabling direct detection of miR-122 in blood, with high specificity and sensitivity from small sample volumes. This assay accurately identifies DILI in humans and animals, offering improved stability and isomiR detection compared to PCR methods.</dc:description>
      <dc:date>2024-02-07T13:22:31Z</dc:date>
      <dc:date>2024-02-07T13:22:31Z</dc:date>
      <dc:date>2020-02-18</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>López-Longarela B, Morrison EE, Tranter JD, Chahman-Vos L, Léonard JF, Gautier JC, Laurent S, Lartigau A, Boitier E, Sautier L, Carmona-Saez P, Martorell-Marugan J, Mellanby RJ, Pernagallo S, Ilyine H, Rissin DM, Duffy DC, Dear JW, Díaz-Mochón JJ. Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges. Anal Chem. 2020 Feb 18;92(4):3388-3395. doi: 10.1021/acs.analchem.9b05449. Epub 2020 Jan 27. PMID: 31939284.</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/88616</dc:identifier>
      <dc:identifier>10.1021/acs.analchem.9b05449</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>embargoed access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>ACS Publications</dc:publisher>
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