Differences in areal bone mineral density between metabolically healthy and unhealthy overweight/obese children: the role of physical activity and cardiorespiratory fitness Ubago Guisado, Esther Gracia Marco, Luis Andrés Medrano, María Cadenas-Sánchez, Cristina Arenaza, Lide Hidalgo Migueles, Jairo Mora González, José Rafael Tobalina, Ignacio Escolano-Margarit, Maria Victoria Oses, Maddi Martín Matillas, Miguel Labayen, Idoia Ortega Porcel, Francisco Bartolomé Bone mineral density Physical Activity “This manuscript was published by SPRINGERNATURE in Pediatric Research on June 2020, available at: doi: 10.1038/s41390-019-0708-x.” OBJECTIVES: To examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children and to examine the role of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF) in this association. METHODS: A cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2 years) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen’s metabolic syndrome cut-off points for triglycerides, glucose, high-density cholesterol and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-m shuttle run test, respectively. Body composition was measured by dual-energy X-ray absorptiometry. RESULTS: In model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen’s d effect size, ES = 0.34), trunk (ES = 0.43) and pelvis (ES = 0.33) than MUO children. These differences were attenuated once MVPA was added to model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3). CONCLUSIONS: This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF seem to partially explain these findings. 2024-02-04T18:09:21Z 2024-02-04T18:09:21Z 2020-06 journal article Ubago-Guisado E, Gracia-Marco L, Medrano M, Cadenas-Sanchez C, Arenaza L, Migueles JH, Mora-Gonzalez J, Tobalina I, Escolano-Margarit MV, Oses M, Martín-Matillas M, Labayen I, Ortega FB. Differences in areal bone mineral density between metabolically healthy and unhealthy overweight/obese children: the role of physical activity and cardiorespiratory fitness. Pediatr Res. 2020 Jun;87(7):1219-1225. doi: 10.1038/s41390-019-0708-x. Epub 2019 Dec 10. PMID: 31822016. https://hdl.handle.net/10481/88187 10.1038/s41390-019-0708-x eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional SPRINGER NATURE in Pediatric Research