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      <dc:title>Radical‐promoted C‐C bond cleavage: a deconstructive approach for selective functionalization</dc:title>
      <dc:creator>Morcillo Martínez, Sara Patricia</dc:creator>
      <dc:description>Just as “Deconstructivism”appearedas anovel movement in archi-tecturein the 1980s,deconstructiveapproaches haverecentlyemergedas excellentstrategiesfor scaffoldhoppingmodificationsin chemistry.The deconstructionand functionalizationof cyclicmoleculesmainlyinvolvesthe cleavageof the carbon–carbon(C@C) bondfollowedbythe constructionof new bonds.The cleavageof inertC@Csinglebonds,especiallyin unstrainedcycles,and theirsubsequentfunctionalizationis still one of the mostsought-afterchallengesin chemistry.Inthis vein,radical-mediatedstrategiesprovidean excellentapproachforachievingthis aim.Thisminireviewis an outlineof the historyofhomolyticcleavageand highlightsthe recentadvancesin exploringnewchemicalspaceby deconstructivefunctionalization.</dc:description>
      <dc:date>2024-01-26T13:48:18Z</dc:date>
      <dc:date>2024-01-26T13:48:18Z</dc:date>
      <dc:date>2019-10</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Angewandte Chemie International Edition 58 (40), 14044-14054</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/87399</dc:identifier>
      <dc:identifier>10.1002/anie.201905218</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Wiley Online Library</dc:publisher>
   </ow:Publication>
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