Flavor recognition memory related activity of the posterior piriform cortex in adult and aged rats Grau Perales, Alejandro Borja Gómez Chacón, Beatriz Morillas, Enrique Gallo Torre, Milagros Aging Flavor C-Fos Attenuation of neophobia Recognition memory Piriform cortex The relationship between the piriform cortex and flavor recognition memory was investigated in adult and aged rats. By using c-Fos immunohistochemistry, we assessed the piriform cortex activity induced by flavor familiarity. The results indicated increased activity in the rostral region of the posterior piriform cortex elicited by the most familiar cider vinegar solution after six exposures. Aged rats exhibited overall increased activity in the posterior, but not the anterior piriform cortex, which was not related to flavor familiarity. This suggests that the posterior piriform cortex is related to flavor recognition memory and that aging modifies its activity pattern which might underlie their slower attenuation of flavor neophobia. 2024-01-26T13:15:57Z 2024-01-26T13:15:57Z 2019 journal article https://hdl.handle.net/10481/87389 10.1016/j.bbr.2018.12.016 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elservier