Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory Grau Perales, Alejandro Borja Gámiz Ruiz, Fernando Gallo Torre, Milagros Rat Hippocampus Taste Memory Attenuation of neophobia Dopamine Taste recognition memory is evident in rodents because the initial neophobia to novel tastes attenuates across exposures as the taste becomes familiar and safe. This attenuation of taste neophobia (AN) is context-dependent and an auditory background change could induce the recovery of the neophobic response. The AN auditory context-dependency requires the hippocampal integrity but the neurochemical mechanisms underlying the interaction with the taste memory circuit remain unexplored. We have applied pharmacological intervention by 6-hidroxydopamine (6-OHDA) hippocampal lesion for assessing the role of catecholamines in the hippocampal system to Wistar rats that drank a novel 3% vinegar solution for several consecutive days. Additionally, we manipulated the auditory background as a context that could either change or remain constant across all the drinking sessions. We found that a disruption of the context-dependent AN was induced by intracerebral administration of 6-OHDA targeted to the ventral CA1 hippocampus (vCA1). We conclude that the ability of the auditory context to modulate taste recognition memory involves the catecholaminergic activity in the ventral hippocampal circuit for the proper acquisition of safe taste memory. 2024-01-17T12:06:59Z 2024-01-17T12:06:59Z 2021 journal article Published version: Grau Perales, A. B. Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory. Behavioural Brain Research Volume 409, 9 July 2021, 113320. [https://doi.org/10.1016/j.bbr.2021.113320] https://hdl.handle.net/10481/86855 10.1016/j.bbr.2021.113320 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier