Effects of dietary choline availability on latent inhibition of flavor aversion learning Gámiz Ruiz, Fernando Recio Rodríguez, Sergio Andrés Iliescu, Adela F. Gallo Torre, Milagros Brugada Sauras, Isabel de Attention Choline Latent inhibition Learning Flavor aversion Rats This work was supported by the research projects PSI2011-23702 and PSI2012-31641 (MINECO, Spain, with FEDER funding). Objective: It has been previously reported that dietary choline supplementation might affect latent inhibition (LI) using a conditioned suppression procedure in rats. We have assessed the effect of dietary choline on LI of flavor aversion learning. Method: Adult male Wistar rats received a choline supplemented (5 g/kg), deficient (0 g/kg), or standard (1.1 g/kg) diet for 3 months. After this supplementation period, all rats went through a conditioned taste aversion (CTA) procedure, half of them being pre-exposed to the conditioned stimulus before the conditioning. Results: The results indicated that choline deficiency prevents LI of conditioned flavor aversion to cider vinegar (3%) induced by a LiCl (0.15 M; 2% body weight) intraperitoneal injection, while choline supplementation enhances CTA leading to slower extinction. Discussion: The role of the brain systems modulating attentional processes is discussed. 2024-01-16T12:49:50Z 2024-01-16T12:49:50Z 2014 journal article Published version: Fernando Gámiz, Sergio Andrés Recio, Adela Florentina Iliescu, Milagros Gallo & Isabel de Brugada (2015) Effects of dietary choline availability on latent inhibition of flavor aversion learning. Nutritional Neuroscience, 18:6, 275-280. [DOI: 10.1179/1476830514Y.0000000129] https://hdl.handle.net/10481/86840 10.1179/1476830514Y.0000000129 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Taylor and Francis