Human decidual stromal cells secrete soluble pro-apoptotic factors during decidualization in a cAMP-dependent manner Leno-Durán, Esther Ruiz Magaña, María José Muñoz Fernández, Raquel García Olivares, Enrique Ruiz Ruiz, Carmen DSC Apoptosis Decidualization Decidualization triggers the secretion of soluble factors that induce apoptosis in DSC. The differentiation and apoptosis of DSC during decidualization of the receptive decidua are crucial processes for the controlled invasion of trophoblasts in normal pregnancy. Most DSC regress in a time-dependent manner, and their removal is important to provide space for the embryo to grow. However, the mechanism that controls DSC death is poorly understood. DSCs were resistant to a variety of apoptosis-inducing substances. Nevertheless, DSC underwent apoptosis during decidualization in culture, withcAMPbeing essential for both apoptosis and differentiation. In addition, culture supernatants from decidualizedDSCinduced apoptosis in undifferentiatedDSC, although paradoxically these supernatants decreased the spontaneous apoptosis of decidual lymphocytes. Exogenously added PRLdid not induce apoptosis inDSCand an antibody that neutralized the PRLreceptor did not decrease the apoptosis induced by supernatants. 2024-01-02T17:48:33Z 2024-01-02T17:48:33Z 2014-08-14 journal article E. Leno-Durán, M.J. Ruiz-Magaña, R. Muñoz-Fernández, E.G. Olivares y C. Ruiz-Ruiz. Human decidual stromal cells secrete soluble pro-apoptotic factors during decidualization in a cAMP-dependent manner. Hum Reprod. 2014 Oct 10;29(10):2269-77 https://hdl.handle.net/10481/86511 10.1093/humrep/deu202 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License OXFORD JOURNALS