Lateral habenula lesions disrupt appetitive extinction, but do not affect voluntary alcohol consumption Donaire, Rocío Morón, Ignacio Blanco, Santos Villatoro, Álvaro Gámiz, Fernando Papini, Mauricio R. Torres, Carmen Lateral habenula Reward loss Consummatory extinction Instrumental extinction Voluntary alcohol consumption Research supported by Grants (PSI-2013-44945-P and PSI2017-87340-P) to CT and by a Fulbright US Scholar Award to MRP. The authors thank A. Ibáñez and A. Chica for their assistance, and the University of Jaén for services provided (SCAI). This study analyzed the effects of LHb lesions on appetitive extinction and alcohol consumption. Eighteen male Wistar rats received neurochemical lesions of the LHb (quinolinic acid) and 12 received a vehicle infusion (PBS). In a runway instrumental task, rats received acquisition (12 pellets/trial, 6 trials/session, 10 sessions) and extinction training (5 sessions). In a consummatory task, rats had daily access to 32% sucrose (5 min, 10 sessions) followed by access to water (5 sessions). Then, animals received 2 h preference tests with escalating alcohol concentrations (2%–24%), followed by two 24 h preference tests with 24% alcohol. Relative to Shams, LHb lesions delayed extinction, as indicated by lower response latencies (instrumental task) and higher fluid consumption (consummatory task). LHb lesions did not affect alcohol consumption regardless of alcohol concentration or test duration. The LHb modulates appetitive extinction and needs to be considered as part of the brain circuit underlying reward loss. 2023-12-14T11:02:42Z 2023-12-14T11:02:42Z 2019-06-11 info:eu-repo/semantics/article Donaire, Rocío et al. Lateral habenula lesions disrupt appetitive extinction, but do not affect voluntary alcohol consumption. Neuroscience Letters Volume 703, 11 June 2019, Pages 184-190. https://doi.org/10.1016/j.neulet.2019.03.044 https://hdl.handle.net/10481/86203 10.1016/j.neulet.2019.03.044 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier