Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis Nogueras Pérez, Raquel Heredia-Nicolás, Noelia Lara-Peña, Laura de López de Andrés, Julia Marchal Corrales, Juan Antonio Jiménez González, Gema Griñán Lisón, Carmen Breast cancer stem cells miRNAs Diagnostic Prognostic Signature This research was funded by Consejería de Salud y Familias de la Junta de Andalucía (project no. PIN-0224-2019 and PEMP-0205-2022 FEDER funds); the Ministerio de Ciencia e Innovación (project no. PID2022-140151OB-C22); the Convocatoria de Proyectos Intramurales ibs.GRANADA (project no. INTRAIBS-2020-1 and INTRAIBS-2021-09) and by the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963). Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation within the tumor possesses unique characteristics, including tumor-initiating capabilities, contributes to treatment resistance, and plays a role in cancer recurrence and metastasis. In recent years, microRNAs (miRNAs) have emerged as potential regulators of BCSCs, which can modulate gene expression and influence cellular processes like BCSCs' self-renewal, differentiation, and tumor-promoting pathways. Understanding the miRNA signatures of BCSCs holds great promise for improving BC diagnosis and prognosis. By targeting BCSCs and their associated miRNAs, researchers aim to develop more effective and personalized treatment strategies that may offer better outcomes for BC patients, minimizing tumor recurrence and metastasis. In conclusion, the investigation of miRNAs as regulators of BCSCs opens new directions for advancing BC research through the use of bioinformatics and the development of innovative therapeutic approaches. This review summarizes the most recent and innovative studies and clinical trials on the role of BCSCs miRNAs as potential tools for early diagnosis, prognosis, and resistance. 2023-12-12T11:09:12Z 2023-12-12T11:09:12Z 2023-11-06 journal article Nogueras Pérez, R.; Heredia-Nicolás, N.; de Lara-Peña, L.; López de Andrés, J.; Marchal, J.A.; Jiménez, G.; Griñán-Lisón, C. Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis. Int. J. Mol. Sci. 2023, 24, 16010. [https://doi.org/10.3390/ijms242116010] https://hdl.handle.net/10481/86117 10.3390/ijms242116010 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI