Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents Prieto Gómez, Isabel Durán Ogalla, Raquel Vives Montero, Francisco Domínguez Vías, German Brain asymmetry Neuro-endocrine asymmetry Neuro-visceral integration Hypertension Renin-angiotensin system Aminopeptidases Frontal cortex Hypothalamus Pituitary Adrenal Supplementary Materials: The supporting information can be downloaded at: https://www.mdpi. com/article/10.3390/ijms242116007/s1 It has been suggested that the neuro-visceral integration works asymmetrically and that this asymmetry is dynamic and modifiable by physio-pathological influences. Aminopeptidases of the renin–angiotensin system (angiotensinases) have been shown to be modifiable under such conditions. This article analyzes the interactions of these angiotensinases between the left or right frontal cortex (FC) and the same enzymes in the hypothalamus (HT), pituitary (PT), adrenal (AD) axis (HPA) in control spontaneously hypertensive rats (SHR), in SHR treated with a hypotensive agent in the form of captopril (an angiotensin-converting enzyme inhibitor), and in SHR treated with a hypertensive agent in the form of the L-Arginine hypertensive analogue L-NG-Nitroarginine Methyl Ester (L-NAME). In the control SHR, there were significant negative correlations between the right FC with HPA and positive correlations between the left FC and HPA. In the captopril group, the predominance of negative correlations between the right FC and HPA and positive correlations between the HPA and left FC was maintained. In the L-NAME group, a radical change in all types of interactions was observed; particularly, there was an inversion in the predominance of negative correlations between the HPA and left FC. These results indicated a better balance of neuro-visceral interactions after captopril treatment and an increase in these interactions in the hypertensive animals, especially in those treated with L-NAME. 2023-12-12T10:53:58Z 2023-12-12T10:53:58Z 2023-11-06 journal article Prieto, I.; Segarra, A.B.; Banegas, I.; Martínez-Cañamero, M.; Durán, R.; Vives, F.; Domínguez-Vías, G.; Ramírez-Sánchez, M. Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents. Int. J. Mol. Sci. 2023, 24, 16007. [https://doi.org/10.3390/ijms242116007] https://hdl.handle.net/10481/86114 10.3390/ijms242116007 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI