The Potential of Mangifera indica L. Peel Extract to Be Revalued in Cosmetic Applications García-Villegas, Abigail Andreina Fernández Ochoa, Álvaro Rojas García, Alejandro Arráez Román, David Cádiz Gurrea, María de la Luz Segura Carretero, Antonio Mango By-products Phenolic compounds Antioxidants Skin health Anti-aging Cosmeceuticals This research was funded by the Regional Ministry of Economy, Knowledge, Enterprise, and Universities of Andalusia grant number P18-TP-3589. The author A.G.-V. expresses gratitude to the project P18-TP-3589, as well as to the University of Granada and AGR274 group for her contract. Á.F.-O. would like to thank the Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia for the contract for Young Researchers (PAIDI) at the University of Granada. A.R.-G. would like to thank the Spanish Ministry of Science, Innovation, and Universities for the grant FPU21/02714. M.d.l.L.C.-G. thanks her contract RYC2021-032119-I founded by MCIN/AEI/10.13039/501100011033 and NextGenerationEU/PRTR. The authors are also grateful to the Company “Grupo Empresarial La Caña” for ensuring traceability assurance of the samples and for its commitment to the research group and I+D+i. The constant growth of the cosmetic industry, together with the scientific evidence of the beneficial properties of phytochemicals, has generated great interest in the incorporation of bioactive extracts in cosmetic formulations. This study aims to evaluate the bioactive potential of a mango peel extract for its incorporation into cosmetic formulations. For this purpose, several assays were conducted: phytochemical characterization; total phenolic content (TPC) and antioxidant potential; free-radical scavenging capacity; and skin aging-related enzyme inhibition. In addition, the extract was incorporated into a gel formulation, and a preliminary stability study was conducted where the accelerated (temperature ramp, centrifugation, and heating/cooling cycles) and long-term (storage in light and dark for three months) stability of the mango peel formulations were evaluated. The characterization results showed the annotation of 71 compounds, gallotannins being the most representative group. In addition, the mango peel extract was shown to be effective against the center dot NO radical with an IC50 of 7.5 mg/L and against the hyaluronidase and xanthine oxidase enzymes with IC50 of 27 mg/L and 2 mg/L, respectively. The formulations incorporating the extract were stable during the stability study. The results demonstrate that mango peel extract can be a by-product to be revalorized as a promising cosmetic ingredient. 2023-12-11T09:47:09Z 2023-12-11T09:47:09Z 2023-10-21 journal article García-Villegas, A.; Fernández-Ochoa, Á.; Rojas-García, A.; Alañón, M.E.; Arráez-Román, D.; Cádiz-Gurrea, M.d.l.L.; Segura-Carretero, A. The Potential of Mangifera indica L. Peel Extract to Be Revalued in Cosmetic Applications. Antioxidants 2023, 12, 1892. [https://doi.org/10.3390/antiox12101892] https://hdl.handle.net/10481/86093 10.3390/antiox12101892 eng info:eu-repo/grantAgreement/EC/NextGenerationEU/RYC2021-032119-I http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI