Preclinical Evidence for the Use of Oral Mesenchymal Stem Cell-Derived Extracellular Vesicles in Bone Regenerative Therapy: A Systematic Review Olaechea, Allinson Benabdellah, Karim Padial Molina, Miguel Galindo Moreno, Pablo Antonio Cellular therapy Extracellular vesicles Oral mesenchymal stem cells Bone regeneration Preclinical models Angiogenesis Osteogenesis Proinflammatory cytokines Tissue engineering is a relatively recent research area aimed at developing artificial tissues that can restore, maintain, or even improve the anatomical and/or functional integrity of injured tissues. Otolaryngology, as a leading surgical specialty in head and neck surgery, is a candidate for the use of these advanced therapies and medicinal products developed. Nevertheless, a knowledge-based analysis of both areas together is still needed. The dataset was retrieved from the Web of Science database from 1900 to 2020. SciMAT software was used to perform the science mapping analysis and the data for the biomedical translation identification was obtained from the iCite platform. Regarding the analysis of the cognitive structure, we find consolidated research lines, such as the generation of cartilage for use as a graft in reconstructive surgery, reconstruction of microtia, or the closure of perforations of the tympanic membrane. This last research area occupies the most relevant clinical translation with the rest of the areas presenting a lower translational level. In conclusion, Tissue engineering is still in an early translational stage in otolaryngology, otology being the field where most advances have been achieved. Therefore, although otolaryngologists should play an active role in translational research in tissue engineering, greater multidisciplinary efforts are required to promote and encourage the translation of potential clinical applications of tissue engineering for routine clinical use 2023-10-27T07:53:33Z 2023-10-27T07:53:33Z 2023-09-16 info:eu-repo/semantics/article Allinson Olaechea, Karim Benabdellah, Andrea Vergara-Buenaventura, Sara Gómez-Melero, Emilio A Cafferata, Jonathan Meza-Mauricio, Miguel Padial-Molina, Pablo Galindo-Moreno, Preclinical Evidence for the Use of Oral Mesenchymal Stem Cell-Derived Extracellular Vesicles in Bone Regenerative Therapy: A Systematic Review, Stem Cells Translational Medicine, 2023;, szad059, [10.1093/stcltm/szad059] https://hdl.handle.net/10481/85292 10.1093/stcltm/szad059 eng http://creativecommons.org/licenses/by-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NoDerivatives 4.0 Internacional Oxford University Press