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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/85243">
      <dc:title>Moving into the red – a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps</dc:title>
      <dc:creator>Rodriguez Rios, Maria</dc:creator>
      <dc:creator>Megía Fernández, Alicia</dc:creator>
      <dc:description>Neutrophils are the first immune cells recruited for defence against invading pathogens; however, their dysregulated activation and subsequent release of the enzyme human neutrophil elastase is associated with several, inflammation-based, diseases. Herein, we describe a FRET-based, tri-branched (one quencher, three fluorophores) near infrared probe that provides an intense OFF/ON amplified fluorescence signal for specific detection of human neutrophil elastase. The probe allowed selective detection of activated neutrophils and labelling of neutrophil extracellular traps.&#xd;
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A tri-branched, FRET-based probe for the detection of hNE was synthesised with emission in the NIR region of the spectrum, where endogenous biomolecules have decreased absorbance, and minimal autofluorescence</dc:description>
      <dc:date>2023-10-25T10:23:16Z</dc:date>
      <dc:date>2023-10-25T10:23:16Z</dc:date>
      <dc:date>2023-09</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Chem. Commun., 2023, 59, 11660[DOI: 10.1039/d3cc03634k]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/85243</dc:identifier>
      <dc:identifier>10.1039/d3cc03634k</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>Royal Society of Chemistry</dc:publisher>
   </ow:Publication>
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