The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer Campa, Daniele Sáinz Pérez, Juan Pancreatic cancer Pancreatic ductal adenocarcinoma Pancreatic neuroendocrine tumors Intraductal papillary mucinous neoplasms Intraductal papillary mucinous neoplasms Chronic pancreatitis Genetic epidemiology Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups 2023-10-13T11:52:51Z 2023-10-13T11:52:51Z 2023-05-08 journal article D. Campa et al. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. Critical Reviews in Oncology / Hematology 186 (2023) 104020[https://doi.org/10.1016/j.critrevonc.2023.104020] https://hdl.handle.net/10481/84971 10.1016/j.critrevonc.2023.104020 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Elsevier