Pancreatitis crónica: análisis de factores de progresión de la enfermedad Diéguez Castillo, Carmelo Jiménez Luna, Cristina Prados Salazar, José Carlos Caba Pérez, Octavio Alcohol Drinking Pancreatitis, Chronic Tobacco Background: Alcohol and tobacco are important risk factors for chronic pancreatitis (CP). Aim: To analyze the effect of etiological factors such as tobacco and alcohol and pancreatic enzyme replacement therapy (PERT) in the progression of CP. Material and Methods: Patients with a diagnosis of CP were recruited and grouped according to variables such as tobacco, alcohol and PERT. They were followed for 18 months. Subsequently, different variables and analytical parameters involved in the progression of the disease were analyzed. Results: A total of 50 patients diagnosed with CP were included. Of these, 28 patients underwent PERT, 39 were smokers and 33 were alcohol users. Compared with patients without PERT, those with PERT had a higher proportion of diabetes (64 and 32%, respectively), had a higher need for endoscopic treatment (25 and 0%, respectively) and a normal body mass index (71 and 27.3%, respectively. The smokers had higher calcium levels and increased lymphocytosis and leukocytosis. The alcohol consumption group had a higher mean age (p = 0.04) Conclusions: PERT may improve the nutritional status but does not reduce the need for endoscopic or surgical treatment. Smoking and alcohol consumption favored the progression of CP. Also, smoking induced a pro-inflammatory state. 2023-10-04T08:22:45Z 2023-10-04T08:22:45Z 2022-12 journal article C. Diéguez et al. Pancreatitis crónica: análisis de factores de progresión de la enfermedad. Rev Med Chile 2022; 150: 1555-1564. [http://dx.doi.org/10.4067/s0034-98872022001201555] https://hdl.handle.net/10481/84819 10.4067/s0034-98872022001201555 spa http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Sociedad Medica de Santiago de Chile