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      <dc:title>Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis</dc:title>
      <dc:creator>López Ansio, María</dc:creator>
      <dc:creator>Ramos García, Pablo</dc:creator>
      <dc:creator>González Moles, Miguel Ángel</dc:creator>
      <dc:subject>Retinoblastoma</dc:subject>
      <dc:subject>PRb</dc:subject>
      <dc:subject>Oral cancer</dc:subject>
      <dc:subject>Prognosis</dc:subject>
      <dc:subject>Systematic review</dc:subject>
      <dc:subject>Meta-analysis</dc:subject>
      <dc:description>This systematic review and meta-analysis aims to evaluate the scientific evidence on the implications&#xd;
of retinoblastoma protein (pRb) alterations in oral cancer, in order to determine its prognostic&#xd;
and clinicopathological significance. PubMed, Embase, Web of Science, and Scopus were searched&#xd;
for studies published before February 2022, with no restrictions by publication date or language. The&#xd;
quality of the studies using the Quality in Prognosis Studies tool (QUIPS tool). Meta-analysis was&#xd;
conducted to achieve the proposed objectives, as well as heterogeneity, subgroup, meta-regression,&#xd;
and small study-effects analyses. Twenty studies that met the inclusion criteria (2451 patients) were&#xd;
systematically reviewed and meta-analyzed. Our results were significant for the association between&#xd;
the loss of pRb expression and a better overall survival (HR = 0.79, 95%CI = 0.64–0.98, p = 0.03),&#xd;
whereas no significant results were found for disease-free survival or clinico-pathological parameters&#xd;
(T/N status, clinical stage, histological grade). In conclusion, our evidence-based results demonstrate&#xd;
that loss of pRb function is a factor associated with improved survival in patients with OSCC.&#xd;
Research lines that should be developed in the future are highlighted</dc:description>
      <dc:date>2023-07-26T08:39:38Z</dc:date>
      <dc:date>2023-07-26T08:39:38Z</dc:date>
      <dc:date>2023-06-09</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>López-Ansio, M.; Ramos-García, P.; González-Moles, M.Á. Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers 2023, 15, 3132. [https://doi.org/10.3390/ cancers15123132]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/84008</dc:identifier>
      <dc:identifier>10.3390/cancers15123132</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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