Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice Celidwen, Yuria Añaños Bedriñana, Karen Giovanna Indigenous peoples Traditional medicine Traditional healing Psychedelics Ethics Traditional ecological knowledge Plant medicine Spirit medicine The resurgence of Western psychedelic research and practice has led to increasing concerns from many Indigenous Nations regarding cultural appropriation, lack of recognition of the sacred cultural positioning of these medicines, exclusionary practices in research and praxis, and patenting of traditional medicines. Indigenous voices and lead-ership have been notably absent from the Western psychedelic field currently widely represented by Westerners. An Indigenous-led globally represented group of practitioners, activists, scholars, lawyers, and human rights defenders came together with the purpose of formulating a set of ethical guidelines concerning traditional Indigenous medi-cines current use in Western psychedelic research and practice. A global Indigenous consensus process of knowledge-gathering was engaged which identified eight interconnected ethical principles, including: Reverence, Respect, Responsibility, Relevance, Regulation, Reparation, Restoration, and Reconciliation. A summary of the work is presented here with suggested ethical actions for moving forward within Western psychedelic research and practice spaces. Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 2023-07-25T11:29:42Z 2023-07-25T11:29:42Z 2023-02 journal article Celidwen, Y. et al. Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice. The Lancet Regional Health - Americas Volume 18, February 2023, 100410. [https://doi.org/10.1016/j.lana.2022.100410] https://hdl.handle.net/10481/83980 10.1016/j.lana.2022.100410 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier