Widespread distribution and altered pain processing in head and neck cancer survivors at long‑term after treatment Hernández Hernández, Sofía Martín-Núñez, Javier Heredia Ciuró, Alejandro Navas-Otero, Alba Valenza , Marie Carmen Head and neck Cancer Pain Radiotherapy Hypersensitivity Funding for open access publishing: Universidad de Granada/CBUA PurposeRadiotherapy (RT) treatment in head and neck cancer (HNC) patients may induce long-term sequels as pain, which nowadays is not fully understand. Therefore, there is a need of characterization of pain features in HNC to enhance after oncology treatment management. Head and neck cancer survivors develop chronic pain after radiotherapy treatment. The purpose of the current study is to evaluate the presence of pain, pain distribution, and pain processing by means of patient reported outcomes and quantitative sensory testing.MethodsPain pressure threshold (PPT), temporal summation (TS), Brief Pain Inventory (BPI), Widespread Pain Index (WPI), The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, and EuroQol5D5L were assessed in 20 head and neck cancer survivors (sHNC) and 20 health-related sex and age-matched controls.ResultsThe sHNC present lower PPT values in both the affected and non-affected side than did the healthy controls, especially in the widespread pain in the body, an altered TS in both affected and non-affected side and lower scores in quality of life and arm dysfunction.ConclusionsFollowing radiotherapy treatment after 1 year, sHNC present widespread pain, hypersensitivity in the radiated area, altered pain processing, upper limb affection, and a QoL diminution. These data provide evidence that a peripheral and central sensitization is happening in sHNC. Future efforts should focus on preventing pain after oncologic treatment. The comprehension about pain and its features in sHNC enhance health professional understanding and allows to tailor an optimal patient-targeted pain treatment. 2023-07-18T11:52:21Z 2023-07-18T11:52:21Z 2023-06-14 journal article Hernández, S.H., Guía, V.G.J., Núñez, J.M. et al. Widespread distribution and altered pain processing in head and neck cancer survivors at long-term after treatment. Support Care Cancer 31, 394 (2023). [https://doi.org/10.1007/s00520-023-07846-9] https://hdl.handle.net/10481/83852 10.1007/s00520-023-07846-9 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature