Elucidating the Therapeutic Potential of Bis(Maltolato)OxoVanadium(IV): The Protective Role of Copper in Cellular Metabolism Rivas García, Lorenzo Varela López, Alfonso Quiles Morales, José Luis Montes Bayón, María Aranda Ramírez, Pilar Llopis González, Juan Sánchez González, Cristina Vanadium Copper Mineral Nutrition Mitochondria DNA Vanadium (V) is a trace mineral whose biological activity, role as a micronutrient, and pharmacotherapeutic applications remain unknown. Over the last years, interest in V has increased due to its potential use as an antidiabetic agent mediated by its ability to improve glycemic metabolism. However, some toxicological aspects limit its potential therapeutic application. The present study aims to evaluate the effect of the co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) as a possible strategy to reduce the toxicity of BMOV. Treating hepatic cells with BMOV reduced cell viability under the present conditions, but cell viability was corrected when cells were co-incubated with BMOV and Cu. Additionally, the effect of these two minerals on nuclear and mitochondrial DNA was evaluated. Co-treatment with both metals reduced the nuclear damage caused by BMOV. Moreover, treatment with these two metals simultaneously tended to reduce the ND1/ND4 deletion of the mitochondrial DNA produced with the treatment using BMOV alone. In conclusion, these results showed that combining Cu and V could effectively reduce the toxicity associated with V and enhance its potential therapeutic applications. 2023-07-17T10:36:39Z 2023-07-17T10:36:39Z 2023-05-27 journal article Rivas-García, L.; López- Varela, A.; Quiles, J.L.; Montes-Bayón, M.; Aranda, P.; Llopis, J.; Sánchez- González, C. Elucidating the Therapeutic Potential of Bis(Maltolato)OxoVanadium(IV): The Protective Role of Copper in Cellular Metabolism. Int. J. Mol. Sci. 2023, 24, 9367. [https://doi.org/10.3390/ ijms2411936]7 https://hdl.handle.net/10481/83815 10.3390/ ijms24119367 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI