A mesoporous Zr-based metal–organic framework driven by the assembly of an octatopic linker Ortín Rubio, Borja Carmona Fernández, Francisco Jesús Metal–organic frameworks (MOFs) based on high-connected nets are generally very attractive due to their combined robustness and porosity. Here, we describe the synthesis of BCN-348, a new high-connected Zr-MOF built from an 8-connected (8-c) cubic Zroxocluster and an 8-c organic linker. BCN-348 contains a minimal edge-transitive 3,4,8-c eps net, and combines mesoporosity with thermal and hydrolytic stability. Encouraging results from preliminary studies on its use as a catalyst for hydrolysis of a nerve-agent simulant suggest its potential as an agent for detoxification of chemical weapons and other pernicious compounds. 2023-06-28T09:26:52Z 2023-06-28T09:26:52Z 2023-06-20 journal article Chem. Commun., 2023, 59, 7803[DOI: 10.1039/d3cc01831h] https://hdl.handle.net/10481/82918 10.1039/d3cc01831h eng info:eu-repo/grantAgreement/EC/H2020/101019003 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Royal Society of Chemstry