Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study López-Herreros, J. Jiménez Moleón, José Juan Health-related quality of life Mortality SF-36 Cohort SUN Project This project was made possible by funding from the Spanish Government- Instituto de Salud Carlos III , and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658 , PI10/02293 , PI13/00615 , PI14/01668 , PI14/01798 , PI14/01764 , PI17/01795 , PI18/00631 , PI20/00564 and G03/140 ), from the Government of Navarra ( 27/2011 , 45/2011 , 122/2014 ), from the National Plan on Drugs ( 2020/021 ) as well as from the University of Navarra . Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet. 2023-06-21T11:31:49Z 2023-06-21T11:31:49Z 2023-05 journal article J. López-Herreros et al. Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study. Experimental Gerontology 178 (2023) 112224. [https://doi.org/10.1016/j.exger.2023.112224] https://hdl.handle.net/10481/82702 10.1016/j.exger.2023.112224 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier