The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice Molina Tijeras, José Alberto Ruiz Malagón, Antonio Jesús Hidalgo García, Laura Díez Echave, Patricia Rodríguez Sojo, María Jesús Cádiz Gurrea, María de la Luz Segura Carretero, Antonio Rodríguez Cabezas, María Elena Gálvez Peralta, Julio Juan Rodríguez Nogales, Alba Vezza, Teresa Algieri, Francesca Obesity High-fat diet Insulin resistance Inflammation Lavandula multifida Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it is urgent to improve the management of obesity and its comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this regard, the present study aimed to investigate a well-characterized extract of Lavandula multifida (LME) in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly, the daily administration of LME reduced weight gain as well as improved insulin sensitivity and glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose tissue by decreasing the expression of various proinflammatory mediators (Il-6, Tnf-a, Il-1b, Jnk-1, Ppara, Pparg, and Ampk) and prevented increased gut permeability by regulating the expression of mucins (Muc-1, Muc-2, and Muc-3) and proteins implicated in epithelial barrier integrity maintenance (Ocln, Tjp1, and Tff-3). In addition, LME showed the ability to reduce oxidative stress by inhibiting nitrite production on macrophages and lipid peroxidation. These results suggest that LME may represent a promising complementary approach for the management of obesity and its comorbidities. 2023-06-06T10:37:10Z 2023-06-06T10:37:10Z 2023-03-29 journal article Molina-Tijeras, J.A.; Ruiz- Malagón, A.J.; Hidalgo-García, L.; Diez-Echave, P.; Rodríguez-Sojo, M.J.; Cádiz-Gurrea, M.d.l.L.; Segura- Carretero, A.; del Palacio, J.P.; González-Tejero, M.R.; Rodríguez- Cabezas, M.E.; et al. The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice. Antioxidants 2023, 12, 832. [https://doi.org/10.3390/ antiox12040832] https://hdl.handle.net/10481/82281 10.3390/ antiox12040832 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI