Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases Barungi, Shivan Marchal Corrales, Juan Antonio López Ruiz, Elena Perán, Macarena Cardiovascular diseases Coronary artery disease Stents Atherosclerosis Cancer Nanotechnology Vascular tissue engineering PH-C is supported by an FPU grant from the Ministry of Education, Culture and Sport. This work has been partially funded by the University of Jaen, Acción I apoyo a la investigación (BIO-349) and by Modeling Nature (MNat), Project number QUAL21-11. Cardiovascular diseases (CVD) are the leading causes of death and disability in the world. Among all CVD, the most common is coronary artery disease (CAD). CAD results from the complications promoted by atherosclerosis, which is characterized by the accumulation of atherosclerotic plaques that limit and block the blood flow of the arteries involved in heart oxygenation. Atherosclerotic disease is usually treated by stents implantation and angioplasty, but these surgical interventions also favour thrombosis and restenosis which often lead to device failure. Hence, efficient and long-lasting therapeutic options that are easily accessible to patients are in high demand. Advanced technologies including nanotechnology or vascular tissue engineering may provide promising solutions for CVD. Moreover, advances in the understanding of the biological processes underlying atherosclerosis can lead to a significant improvement in the management of CVD and even to the development of novel efficient drugs. To note, over the last years, the observation that inflammation leads to atherosclerosis has gained interest providing a link between atheroma formation and oncogenesis. Here, we have focused on the description of the available therapy for atherosclerosis, including surgical treatment and experimental treatment, the mechanisms of atheroma formation, and possible novel therapeutic candidates such as the use of anti- inflammatory treatments to reduce CVD. 2023-05-22T10:32:52Z 2023-05-22T10:32:52Z 2023-03-16 info:eu-repo/semantics/article Barungi S, Hernández-Camarero P, Moreno-Terribas G, Villalba-Montoro R, Marchal JA, López-Ruiz E and Perán M (2023), Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases. Front. Cell Dev. Biol. 11:1148768. doi: 10.3389/fcell.2023.1148768 https://hdl.handle.net/10481/81712 10.3389/fcell.2023.1148768 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional Frontiers Media