In Vitro Antitumor and Anti-Inflammatory Activities of Allium-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS) Guillamón, Enrique Martínez Férez, Antonio Antitumor Anti-inflammatory Allium Organosulfur compound Increasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of Allium metabolites and extracts has been proposed to reduce the proliferation of tumor cells by several mechanisms. In this study, we have shown the in vitro anti-proliferative and antiinflammatory effect of two onion-derived metabolites propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO) on several human tumor lines (MCF-7, T-84, A-549, HT-29, Panc-1, Jurkat, PC-3, SW-837, and T1-73). We observed that this effect was related to their ability to induce apoptosis regulated by oxidative stress. In addition, both compounds were also able to reduce the levels of some pro-inflammatory cytokines, such as IL-8, IL-6, and IL-17. Therefore, PTS and PTSO may have a promising role in cancer prevention and/or treatment 2023-05-18T09:49:48Z 2023-05-18T09:49:48Z 2023-03-11 journal article Guillamón, E.;Mut-Salud, N.; Rodríguez-Sojo,M.J.; Ruiz-Malagón, A.J.; Cuberos-Escobar, A.;Martínez- Férez, A.; Rodríguez-Nogales, A.; Gálvez, J.; Baños, A. In Vitro Antitumor and Anti-Inflammatory Activities of Allium-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS). Nutrients 2023, 15, 1363. https://doi.org/10.3390/nu15061363`] https://hdl.handle.net/10481/81645 10.3390/nu15061363 eng ;10.3390/nu15061363 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI