Ejaculation Frequency and Prostate Cancer: CAPLIFE Study Lozano Lorca, Macarena Olmedo Requena, María Rocío Barrios Rodríguez, Rocío Rodríguez Barranco, Miguel Jiménez Moleón, José Juan Ejaculation CAPLIFE study Case-control studies Prostate cancer Sexual activity Purpose To evaluate the association between ejaculation frequency (EF) during four stages of life and prostate cancer (PCa) according to tumor aggressiveness, PCa stage, and urinary symptomatology. Materials and Methods A total of 456 incident PCa cases histologically confirmed, and 427 controls aged 40–80 years from the CAPLIFE study were analyzed. This study is a population-based case-control study carried out in the south of Spain. Average EF was measured for: (1) 20s, (2) 30s, (3) 40s, and (4) one year before the interview. EF was categorized into: (1) 0–3, (2) 4, and (3) >4 ejaculations/month. Sociodemographic, lifestyle, and medical information were also collected. To estimate the association between EF and PCa, adjusted ORs (aORs) and 95% CIs were calculated by logistic regression models. Results A year before the interview, PCa cases ejaculated less frequently than the controls. An inverse association was observed between the EF a year before and PCa, aOR=1.64 (95% CI 1.03–2.61) for men with 4 ejaculations/month, and aOR=2.38 (95% CI 1.57–3.60) for men with 0–3 ejaculations/month, compared to men with >4. The association was higher for cases with ISUP 3–5 (aOR=2.76 [95% CI 1.34–5.67] for men with 0–3 ejaculations/month) or with a locally advanced-metastatic tumor (aOR=4.70 [95% CI 1.55–14.29]). Moreover, men with moderate urinary symptoms and 0–3 ejaculations/month had the highest risk, aOR=3.83 (95% CI 1.84–7.95). Conclusions A low EF could be associated with a higher risk of PCa, especially for cases with ISUP 3–5 or with a locally advanced-metastatic tumor. 2023-05-18T07:57:08Z 2023-05-18T07:57:08Z 2023-03-27 info:eu-repo/semantics/article Lozano-Lorca M, Olmedo-Requena R, Barrios-Rodríguez R, Jiménez-Pacheco A, Vázquez-Alonso F, Castillo-Bueno HM, Rodríguez-Barranco M, Jiménez-Moleón JJ. Ejaculation Frequency and Prostate Cancer: CAPLIFE Study. World J Mens Health. 2023;41:e39[https://doi.org/10.5534/wjmh.220216] https://hdl.handle.net/10481/81631 10.5534/wjmh.220216 eng http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional Korean Society for Sexual Medicine and Andrology