New proposal of viral genome representation applied in the classification of SARS-CoV-2 with deep learning de Souza, Luísa C. De Melo Barbosa, Raquel COVID-19 SARS-CoV-2 GSP CGR DFT Deep learning The authors wish to acknowledge the financial support of the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for their financial support. BackgroundIn December 2019, the first case of COVID-19 was described in Wuhan, China, and by July 2022, there were already 540 million confirmed cases. Due to the rapid spread of the virus, the scientific community has made efforts to develop techniques for the viral classification of SARS-CoV-2.ResultsIn this context, we developed a new proposal for gene sequence representation with Genomic Signal Processing techniques for the work presented in this paper. First, we applied the mapping approach to samples of six viral species of the Coronaviridae family, which belongs SARS-CoV-2 Virus. We then used the sequence downsized obtained by the method proposed in a deep learning architecture for viral classification, achieving an accuracy of 98.35%, 99.08%, and 99.69% for the 64, 128, and 256 sizes of the viral signatures, respectively, and obtaining 99.95% precision for the vectors with size 256.ConclusionsThe classification results obtained, in comparison to the results produced using other state-of-the-art representation techniques, demonstrate that the proposed mapping can provide a satisfactory performance result with low computational memory and processing time costs. 2023-05-12T07:10:52Z 2023-05-12T07:10:52Z 2023-03-11 info:eu-repo/semantics/article de Souza et al. New proposal of viral genome representation applied in the classification of SARS-CoV-2 with deep learning. BMC Bioinformatics (2023) 24:92 [https://doi.org/10.1186/s12859-023-05188-1] https://hdl.handle.net/10481/81475 10.1186/s12859-023-05188-1 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional Springer