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      <dc:title>Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition</dc:title>
      <dc:creator>Yammine, S. G.</dc:creator>
      <dc:creator>Sánchez Pérez, María José</dc:creator>
      <dc:subject>Fatty acids</dc:subject>
      <dc:subject>Endometrial cancer</dc:subject>
      <dc:subject>Epidemiology</dc:subject>
      <dc:subject>Diet</dc:subject>
      <dc:description>We would like to thank ‘the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands’ for their contribution and ongoing support to the EPIC Study.</dc:description>
      <dc:description>This work was undertaken during the tenure of a doctoral Fellowship&#xd;
supported by INCa (INCa 2016 − 184), by Fondation ARC pour la recherche sur&#xd;
le cancer (ARC 2019-DOC4) and by IARC.&#xd;
The coordination of EPIC is financially supported by International Agency&#xd;
for Research on Cancer (IARC) and by the Department of Epidemiology and&#xd;
Biostatistics, School of Public Health, Imperial College London which has&#xd;
additional infrastructure support provided by the NIHR Imperial Biomedical&#xd;
Research Centre (BRC). The national cohorts are supported by: Danish&#xd;
Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy,&#xd;
Mutuelle Générale de l’Education Nationale, Institut National de la Santé et&#xd;
de la Recherche Médicale (INSERM) (France); German Cancer Aid, German&#xd;
Cancer Research Center (DKFZ), German Institute of Human Nutrition&#xd;
PotsdamRehbruecke (DIfE), Federal Ministry of Education and Research&#xd;
(BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy,&#xd;
Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry&#xd;
of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR),&#xd;
LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek&#xd;
Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands&#xd;
(The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III&#xd;
(ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia&#xd;
and Navarra, and the Catalan Institute of Oncology - ICO (Spain); Swedish&#xd;
Cancer Society, Swedish Research Council and County Councils of Skåne&#xd;
and Västerbotten (Sweden); Cancer Research UK (C864/A 14136 to EPIC-&#xd;
Norfolk (DOI https://doi.org/10.22025/2019.10.105.00004); C8221/A29017 to&#xd;
EPIC-Oxford), Medical Research Council (MR/N003284/1 and MC_UU_00006/1&#xd;
to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford). (United Kingdom).</dc:description>
      <dc:description>Data Availability&#xd;
For information on how to submit an application for gaining access to EPIC data and/or biospecimens, please follow the instructions at http://epic.iarc.fr/access/index.php.</dc:description>
      <dc:description>Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).&#xd;
&#xd;
Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.&#xd;
&#xd;
Results: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.&#xd;
&#xd;
Conclusion: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.</dc:description>
      <dc:date>2023-05-08T12:09:25Z</dc:date>
      <dc:date>2023-05-08T12:09:25Z</dc:date>
      <dc:date>2023-02-16</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Yammine et al. BMC Cancer (2023) 23:159. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition [https://doi.org/10.1186/s12885-023-10611-0]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/81395</dc:identifier>
      <dc:identifier>10.1186/s12885-023-10611-0</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution 4.0 Internacional</dc:rights>
      <dc:publisher>Springer Nature</dc:publisher>
   </ow:Publication>
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